Birth Defects Lawyers
Birth Defects Lawyers: An antirheumatic drug, ], l,3-trimethyl-/-phenylbiuret, produced strain-specific ventricular septal defects of the heart in rats following high oral doses (Yamakita et al., 1989). The remainder of the teratogens in this group are salts or esters of salicylic acid and are generally used as antirheumatic agents. One member of the group, widely used as a flavoring agent (oil of wmtergreen), methyl salicylate, had teratogenic capability in all four species tested (Warkany and Takacs, 1959; Szabo and Kang, 1969; Overman and AVhite, 1983). Conflicting results occurred in the rat, however, as high doses applied dermally in another study (Infurna et al., 1990) elicited no developmental toxicity. Lack of dermal absorption in the latter instance may account for the difference. 3-PyridylmethyIsaticylate induced skeletal defects in a few mouse fetuses (Cekanova et al., 1974).
Salicylamide treatment produced a high incidence of minor anomalies in hamsters (LaPointe and Harvey, 1964), but apparently was not teratogenic in mice (Wright, 1967) or rats (Koshakji and Schulert, 1973). Congenital defects, primarily of the skeleton, were resultant in both mouse (Larsson et al., 1963) and rat offspring (Warkany and Takacs, 1959) from maternal treatment with sodium salicylate. Among other species, cleft lip-palate, and eye, limb, and tail defects were produced in ferrets (Gulamhusein et al., 1980), while rabbits and guinea pigs suffered no teratogenic effects from sodium salicylale (Mosher, 1938; Jackson, 1948). For more informaiton on Birth Defects Lawyer subscribe to RSS feed.
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